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Considering sepsis-induced AKI pathophysiology, and since cellular oxidative injury plays a crucial role in sepsis-induced AKI, it is reasonable to assume that HBO can have a potential beneficial effect in this experimental setting, but further studies are necessary to confirm this

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The rational to use CoQ10 diet supplementation was to investigate its in vivo efficacy against the mitochondrial oxidative stress, since most previous studies had shown only in vitro CoQ10 action (La Guardia et al., 2013