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12 As a consequence, dehydration of the nucleus pulposus (NP) occurs with subsequent reduction of disc height and shock-absorbing capacity, thus leading to transmission of circumferential forces to the annulus fibrosus (AF) eventually resulting in AF tears which predispose to discogenic LBP, herniations and further degenerative changes

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The five largest ETFs in the U.S., which have over $2.5 trillion in combined assets, have significant weights to these mega cap companies (Figure 2)