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DziamanT.HuzarskiT.GackowskiD.RozalskiR.SiomekA.SzpilaA.GuzJ.LubinskiJ.OlinskiR.2009aElevated level of 8-oxo-7,8-dihydro-2’-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls.12522092213

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Continuous dosing without a break blunts receptor sensitivity and reduces the efficacy of subsequent cycles