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Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation | Nature Reviews Drug Discovery

Chronic Inflammatory Pain Alters Expression of Limbic MAPK Phosphatases

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In established PSC-CCA, we observed coordinated alterations in oncogenic miRNAs, growth factor-related proteins, and depletion of sulfated phenolics and methylxanthines, reflecting extracellular matrix remodeling, inflammatory microenvironment reprogramming, and impaired hepatic detoxification