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The concept of EDH has also evolved over the last twenty or so years, and is now known to encompass not only coupling via diffusible chemical mediators, including K + , lipid mediators and hydrogen peroxide (H 2 O 2 ), but also direct electrical coupling via myoendothelial gap junctions, with research facilitating our understanding of the EC protrusions that form these contacts with the overlying VSMCs through the internal elastic lamina