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The use of peptides to improve physical performance or aesthetics is not formally approved and is often acquired through “research chemicals” whose purity and quality are not guaranteed

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Experimental results suggest that gene therapies including synthetic nitric oxide synthase (NOS) (121, 122), neurotrophic factors (123–125), angiogenic growth factors (126, 127), Ca 2+ -sensitive maxi-K + Channels (128), antifibrotic factors (129), and vasoactive intestinal polypeptide (VIP) (130) may play crucial roles in promoting relaxation of cavernous smooth muscles, preventing fibrosis in cavernous tissue, improving vascular endothelial function, and repairing nerve damage in living organisms