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[92,96] Potent antioxidants, particularly certain plant extracts, can diminish oxidative damage in diabetes by boosting the expression of Nrf2-mediated detoxifying enzymes

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Oral berberine can elevate brain dopamine levels and improve motor function in PD model animals, partly via altering the gut microbiome [26, 43] It also modulates autophagy and mitochondrial function, reducing dopaminergic neuron loss in PD models [44]