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Compared to healthy controls, SCD patients have significantly lower erythrocyte GSH and cysteine concentrations 12 and a faster rate of GSH synthesis, suggesting that the endogenous cysteine supply is insufficient to meet all anabolic demands

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Despite this, the same study reports a progressive increase in baseline depression levels across sessions, pointing to the possibility of loss of efficacy or even symptomatic worsening with continued use (Cuttler et al., 2018)