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The initial management of overdose: After a careful clinical evaluation of the patient the importance of time elapsed since last ingestion or administration, the amount of poison swallowed and discarding the contraindication of certain procedures, the professional will decide whether or not the treatment of general rescue: emesis or gastric lavage, activated charcoal and saline purgative (45 to 60 minutes after the activated carbon), hemodialysis
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The homological resemblance between thyroxine (TH) and particular TH-disrupting chemicals (TH-EDCs), such as PCB metabolites, dioxin (PCDD), and brominated flame retardants, results in binding to the high-affinity TH transport protein, transthyretin TTR, thereby obstructing T4-TTR binding (Grimm et al., 2013)