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Dying cells also release the mitochondrial components mtDNAs, which in their function as DAMPs can activate immune processes as they contain bacteria-like characteristics (unmethylated CpG, formylated peptides) [81]

SC06

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This has the effect of pushing glycolytic intermediates into the pentose phosphate and serine pathways, and inhibition of CDK6 (through treatment with palbociclib, ribociclib, or knockdown of CDK6) depletes the antioxidants NADPH and glutathione, increasing ROS and apoptosis