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Furthermore, the Au-bound MCR-1-S crystal structure (PDB: 6LI6) demonstrates Au ion displacement of Zn(II) in the catalytic site by coordinating to Glu246, Asp465, His466, and TPO285 in a distorted geometry (Figure 6)

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In his statement announcing the FDA’s approval of leucovorin, Makary said that the agency had reached this decision after “a systematic analysis of literature published between 2009-2024”

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