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Taken together, these findings suggest that NAC can cross the intact BBB but then is rapidly eliminated via OAT1 and OAT3 (and perhaps other probenecid-inhibitable membrane transporters)

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Curcumin exerts protective and therapeutic effects in liver diseases related to oxidative stress by inhibiting pro-inflammatory cytokines, reducing lipid peroxidation products, suppressing hepatic stellate cell activation, and preventing Akt activation