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Statistically significant differences for each treatment compared to the control (at α=95%) were assessed using Student’s t -test and one-way ANOVA, where applicable

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pH-sensitive polymeric nanoparticles, micelles, and hydrogels can be engineered to remain stable at physiological pH but degrade or swell under acidic conditions, triggering the controlled release of therapeutic agents precisely at the diseased site [55, 56]