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In the fungus Neurospora crassa , at the start of each cell differentiation step, a hyperoxidant state occurs that leads to the development of conidia (Gessler et al., 2007)

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Future studies incorporating tyrosine hydroxylase (TH) immunohistochemistry, stereological neuron counts, and behavioral endpoints such as rotarod or cylinder testing will be essential to establish whether the metabolic shifts reported here translate to functional neuroprotection in vivo