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Finally, these sulfur-seeking metals and other chemicals have been shown to directly remove reduced glutathione (GSH) from the cell, as well as inhibit the activities of two key enzymes involved in GSH metabolism: GSH synthetase and GSH reductase (Quig, 1998

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Consequently, ferroptosis, cuproptosis, and disulfidptosis may involve interrelated crosstalk mechanisms involving glycolysis and oxidative phosphorylation in the context of circulatory disturbance

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