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Cancer cells that harbor a somatic mutation in these motifs of the NRF2 gene lose the KEAP1–NRF2 interaction and the subsequent constitutive repression of NRF2 activity during unstressed conditions

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Alcohol-induced neuroinflammation and gut inflammation in mice can be attenuated by reducing the bacterial load in the gut with antibiotics (138), suggesting that alcohol-induced inflammation may be related to gut bacteria