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Introduction Amifostine (2-(3-aminopropylamino) ethylsulfanyl phosphonic acid, WR-2721) (AMF), a synthetic aminothiol compound, is used as a cytoprotective agent in cancer in radiotherapy and chemotherapy involving DNA-binding chemotherapeutic agents

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Distal tubular adaptations Even when drug delivery is adequate, diuretic efficacy is often blunted by compensatory sodium reabsorption downstream