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J Clin Endocrinol Metab (1996) 81(9):3312–7.10.1210/jcem.81.9.8784089 169 RankeMBSavageMOChatelainPGPreeceMARosenfeldRGWiltonP

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It works through multiple mechanisms, increasing blood vessel formation around follicles, reducing inflammation, stimulating collagen synthesis in the dermal papilla, and blocking 5-alpha reductase, the enzyme that converts testosterone to the follicle-damaging DHT