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To avoid this issue, 4-fluorophenylhydrazine was added into the reaction mixture to quantitatively convert pyruvate to 2-(2-(4-fluorophenyl)hydrazono)propanoate ( 23 ) and then used for quantification using 1 H-NMR method (Supplementary Fig

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Furthermore, in the PD mouse model, nuclear inclusions containing α-synuclein (α-syn) species have been shown to induce transcriptional alterations involving an increase in p21 expression and additional genes related to SASP

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