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For its part, c-Myc directly activates the transcription of almost all glycolytic genes at normal oxygen levels [435,436], and unlike HIF-1α was also shown to promote the preferential production of PKM2 over PKM1 by changing exon splicing of the PKM transcript and subsequent promotion of aerobic glycolysis [437]

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Preeclamptic placental stress and over expression of mitochondrial HSP70

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