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Patients should be instructed to stop the medication and seek urgent medical care for severe or persistent abdominal pain (especially if radiating to the back), right upper quadrant pain with fever, inability to maintain adequate fluid intake for more than 24 hours, or decreased urine output

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Combining MOTS-c with 5-Amino-1MQ creates synergistic metabolic enhancement by targeting two distinct but complementary pathways: MOTS-c activates AMPK to increase mitochondrial biogenesis and insulin sensitivity, while 5-Amino-1MQ inhibits NNMT to preserve NAD+ levels, which fuel the very pathways MOTS-c activates