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Adverse effects Coffee enemas Serious illnesses, colitis, electrolyte imbalance and even death have been associated with the use of coffee enemas (Eisele 1980)

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Under physiological conditions, the release of Ca 2+ in the endoplasmic reticulum is controlled by ryanodine receptors (RyR), channels controlled by inositol 1,4,5-triphosphate receptors (IP3R), and the translocon [220]